International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) highly conserved across evolution. Although it is considered as the Testis Determining Factor in many non-mammalian species, Dmrt1 disruptions in mice have no impact on testicular differentiation during fetal development. Otherwise, DMRT1 expression was shown to precede SOX9 up-regulation in XX sex-reversed goats (FOXL2-/-). In order to test our hypothesis that DMRT1 would be involved in sex determination in non-murine species, by targeting SOX9 expression, we used CRISPR/Cas9 technology to generate DMRT1 mutant rabbits. We showed that the absence of DMRT1 leads to male-to-female sex reversal in XY homozygous mutants. At 20 days post-conception...
In mammals, sex determination and development is a complex process that involves genetic networks ac...
DM domain transcription factors play important roles in sexual development in a wide variety of spec...
SummaryTranscription factors related to the insect sex-determination gene doublesex (DMRT proteins) ...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 (doublesex and mab-3 related transcription factor 1) is a conserved tran...
International audienceDMRT1 (doublesex and mab-3 related transcription factor 1) is a conserved tran...
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers ...
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers ...
AbstractDmrt1 belongs to the DM domain gene family of conserved sexual regulators. In the mouse Dmrt...
In many species, including mammals, sex determination is genetically based. The sex chromosomes that...
SummaryMammalian sex determination initiates in the fetal gonad with specification of bipotential pr...
In mammals, sex determination and development is a complex process that involves genetic networks ac...
In mammals, sex determination and development is a complex process that involves genetic networks ac...
DM domain transcription factors play important roles in sexual development in a wide variety of spec...
SummaryTranscription factors related to the insect sex-determination gene doublesex (DMRT proteins) ...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 is a transcription factor containing a DNA-binding domain (DM domain) hi...
International audienceDMRT1 (doublesex and mab-3 related transcription factor 1) is a conserved tran...
International audienceDMRT1 (doublesex and mab-3 related transcription factor 1) is a conserved tran...
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers ...
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers ...
AbstractDmrt1 belongs to the DM domain gene family of conserved sexual regulators. In the mouse Dmrt...
In many species, including mammals, sex determination is genetically based. The sex chromosomes that...
SummaryMammalian sex determination initiates in the fetal gonad with specification of bipotential pr...
In mammals, sex determination and development is a complex process that involves genetic networks ac...
In mammals, sex determination and development is a complex process that involves genetic networks ac...
DM domain transcription factors play important roles in sexual development in a wide variety of spec...
SummaryTranscription factors related to the insect sex-determination gene doublesex (DMRT proteins) ...