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Not AvailableThe present study aimed to evaluate the effect of environmentally realistic concentration of TCS on cellular and tissue level in P. hypophthalmus. In this context, experimental fish were exposed to sub-lethal concentrations of TCS viz. 109 and 208 μg L-1 for thirty days including a control (without TCS) in triplicate and histological study of gills, liver and kidney were performed. TCS exposed fish showed various alterations such as upliftment of gill epithelium, fusion of secondary gill lamellae, curling of gill filaments, necrosis of renal tubules and degeneration of epithelial cells in kidney and degeneration in hepatocytes, damaged sinusoids, aggregation of melanomacrophages in liver. The degree of histological alterations was measured quantitatively as well as qualitatively and showed highest damage with the increase in TCS concentration. Therefore, in the present scenario, there is an urgent need to use this chemical in a holistic way to protect the aquatic environment.Not Availabl