Histopathological Findings in Placentas from Pregnancies Complicated with Preeclampsia

Pathological appearance in preeclampsia placenta giving us information on how the pathophysiology of placental insufficiency as a key role of this syndrome. This study aims to describe the placenta’s histopathological features using hematoxylin and eosin staining procedure from block paraffin on placental tissue. An observational study of 51 placentas samples were collected from preeclampsia patients and stained with hematoxylin and eosin. Results were adjusted for patient’s age at delivery, parity state, gestational age at delivery, and hypertension history before pregnancy. Out of 51 preeclampsia patients that mostly in age of 20-35 years old (64,7%), 34 of them (66,4%) are multiparity, 41 of them with gestational age at delivery in 37-42 weeks, 35 patients (68.6%) without prior history of having hypertension before pregnant and 16 patients (31,4%) with previously hypertension history before pregnant. Villous necrosis, increasing of syncytial knots, and thrombosis of spiralis artery were found in all of the 51 placental samples (100%) while calcification was found in 46 samples (90,2%). Placenta from patients with preeclampsia showed characteristic morphological features of fibrinoid necrosis of the villous, increased syncytial knots, calcification of the villous, and thrombosis of spiralis artery