Add to ORKGIn the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5, has been mapped to chromosome 1. Because mouse chromosome 1 shares a homologous 33-cM region between the genes col3a1 and col6a3 with human chromosome 2q31–q35, several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evidence for at least three type 1 diabetes loci (IDDM7, IDDM12, and IDDM13) within a 23-cM region of chromosome 2q31–q35 (2–5). We have now evaluated linkage on chromosome 2, by multipoint analysis using Mapmaker/Sibs, of 34 microsatellite markers and an interleukin-1 (IL-1) β TaqI polymorphism in 352 U.K. families
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current ther...
The research in this thesis exploits the utility of mouse genetics in the study of type 1 diabetes t...
Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing b...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
Major histocompatibility complex (MHC) plays a large-ly predominant role in the genetic predispositi...
Background One strategy to help identify susceptibility genes for complex, multifact...
Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese d...
As many of the linked chromosome regions that predis-pose to type 1 diabetes in the NOD mouse have b...
BACKGROUND: One strategy to help identify susceptibility genes for complex, multifactorial diseases ...
Genome-wide scans for linkage of chromosome regions to type 1 diabetes in affected sib pair families...
We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes m...
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current ther...
SummaryThe human leukocyte antigen (HLA) complex, encompassing 3.5 Mb of DNA from the centromeric HL...
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current ther...
The research in this thesis exploits the utility of mouse genetics in the study of type 1 diabetes t...
Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing b...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage dis...
Major histocompatibility complex (MHC) plays a large-ly predominant role in the genetic predispositi...
Background One strategy to help identify susceptibility genes for complex, multifact...
Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese d...
As many of the linked chromosome regions that predis-pose to type 1 diabetes in the NOD mouse have b...
BACKGROUND: One strategy to help identify susceptibility genes for complex, multifactorial diseases ...
Genome-wide scans for linkage of chromosome regions to type 1 diabetes in affected sib pair families...
We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes m...
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current ther...
SummaryThe human leukocyte antigen (HLA) complex, encompassing 3.5 Mb of DNA from the centromeric HL...
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current ther...
The research in this thesis exploits the utility of mouse genetics in the study of type 1 diabetes t...
Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing b...