We studied the interactions of two natural thyroid hormone receptor (TR) mutants from patients with resistance to thyroid hormone (RTH) and an artificial TR mutant with a nuclear receptor corepressor, N-CoR, and a steroid receptor coactivator, SRC-1. In electrophoretic mobility shift assays, wild-type TRbeta-1 interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the TRbeta-1/N-CoR complex and formation of TRbeta-1/SRC-1 complex. In contrast, a natural mutant (G345R) with poor T3-binding affinity formed TRbeta-1/N-CoR complex, both in the absence and presence of T3, but could not form TRbeta-1/SRC-1 complex. Another TR mutant, which bound T3 with normal affinity and containing a mutation in the AF-2 region (E457D...
Isoforms of the thyroid hormone receptor (TR) and TR genes mediate thyroid hormone action. How TR i...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
Mutations in the human beta thyroid hormone receptor (h-TRB) gene are associated with the syndrome o...
Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identi...
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that regulate target gene...
Resistance to thyroid hormone (RTH), a human syndrome, is characterized by high thyroid hormone (TH)...
Thyroid hormone receptors (TRs) are ligand inducible transcription factors that can potentially inte...
Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicate...
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by ...
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by ...
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The dis...
Isoforms of the thyroid hormone receptor (TR) and TR genes mediate thyroid hormone action. How TR i...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
International audienceBACKGROUND:Thyroid hormone receptors (TRs) are tightly regulated by the corepr...
Mutations in the human beta thyroid hormone receptor (h-TRB) gene are associated with the syndrome o...
Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identi...
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that regulate target gene...
Resistance to thyroid hormone (RTH), a human syndrome, is characterized by high thyroid hormone (TH)...
Thyroid hormone receptors (TRs) are ligand inducible transcription factors that can potentially inte...
Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicate...
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by ...
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by ...
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The dis...
Isoforms of the thyroid hormone receptor (TR) and TR genes mediate thyroid hormone action. How TR i...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...
Thyroid hormone receptors (TRs) are DNA-binding transcription factors that function through binding ...