Endometrial regeneration in Asherman’s syndrome and endometrial atrophy using Wharton’s jelly-derived mesenchymal stem cells

Objectives: Reconstruction of the endometrium in patients with endometrial atrophy and Asherman’s syndrome usingWharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). Material and methods: Prospective pilot study, with the inclusion of two patients. Results: After administration of WJ-MSCs into the uterine cavity, endometrial reconstruction was achieved in both patients. Pregnancy was achieved in one of them, after transfer of a frozen embryo, completed by delivery around the due date. Conclusions: Endometrial atrophy and Asherman’s syndrome, is one of the most frustrating clinical situations we facein assisted reproductive procedures. The use of Wharton’s jelly-derived mesenchymal stem cells in restoring the normalfunction of the endometrium, could become an easy and accessible therapeutic medal, for this endometrial dysfunction,which is so difficult to treat