Introduction. The present study aimed to investigate the effect of homeodomain interacting protein kinase 2 (HIPK2) on pulmonary fibrosis and the probable mechanisms.Material and methods. We constructed a mouse model of bleomycin-induced pulmonary fibrosis and up-regulated the expression of HIPK2 in the lung by in vivo transfection. Lung tissues were collected for the detection of mesenchymal markers (α-SMA, collagen I, collagen III) and the expression of β-catenin as assessed by RT-PCR, western blot, and immunohistochemistry. Mouse lung fibroblasts (MLFs) with upregulation or downregulation of HIPK2 were successfully constructed and XAV939 was used to downregulate β-catenin expression. Then, we evaluated the activation of MLFs and the Wnt/...
Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. Wh...
Transforming growth factor-beta1 (TGF-beta1) is known to induce the transition of human lung fibrobl...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted ...
Homeodomain-interacting protein kinase 2 (Hipk2) is an emerging player in cell response to genotoxic...
Fibrosis is an unmet medical problem due to a lack of evident biomarkers to help develop efficient t...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abno...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abno...
Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic...
Idiopathic pulmonary fibrosis (IPF) represents the most aggressive form of pulmonary fibrosis (PF) a...
Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic...
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung archite...
Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of resp...
Pulmonary fibrosis is a severe disease that contributes to the morbidity and mortality of a number o...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure. It is clinical...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted ...
Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. Wh...
Transforming growth factor-beta1 (TGF-beta1) is known to induce the transition of human lung fibrobl...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted ...
Homeodomain-interacting protein kinase 2 (Hipk2) is an emerging player in cell response to genotoxic...
Fibrosis is an unmet medical problem due to a lack of evident biomarkers to help develop efficient t...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abno...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abno...
Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic...
Idiopathic pulmonary fibrosis (IPF) represents the most aggressive form of pulmonary fibrosis (PF) a...
Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic...
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung archite...
Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of resp...
Pulmonary fibrosis is a severe disease that contributes to the morbidity and mortality of a number o...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure. It is clinical...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted ...
Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. Wh...
Transforming growth factor-beta1 (TGF-beta1) is known to induce the transition of human lung fibrobl...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted ...