Formulation and Evaluation of Pluronic -Lecithin Organogel Containing Natural Moisturizing Agent for Xerosis

Xerosis is a common skin condition as well as a key aspect of a number of diseases associated to hereditary and acquired conditions. The objective of this study was to formulate and evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application.  Different formulations of pluronic lecithin organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, and potassium sorbate. The gel containing different quantities of Polaxomer, soya lecithin and polyvinyl alcohol were characterized for their mechanical properties and moisturizing capabilities.The pH of the formulations was 6.89- 7.19 reflecting no risk of skin irritation. Pluronic enhances the stability of organogel by increasing the viscosity. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on limbs and feet. Studies showed that the film was intact for longer period of time. The results obtained showed that the polymeric films formed from organogel containing vitamin E and Aloe vera could be an innovative therapeutic approach for enhancing the moisturization of skin. Keywords: Organogel, film forming gel, dry skin, Aloe vera, Vitamin E, soya lecithin, Pluronic F12