A Comprehensive Review on In-Situ Gel Drug Delivery System

Over the past ten years, in situ gelling drug delivery methods have attracted a lot of attention. Prior to injection, they are in a sol-state, and they can gel when exposed to a variety of endogenous stimuli, including temperature rise, pH changes, and the presence of ions. Such to accomplish the injection of a local or systemic medication, systems may be delivered by a variety of can also be employed effectively as carriers for nano- and microparticles that carry drugs. Natural or artificial or in conjunction with semi-artificial polymer exhibiting in situ gelling behaviour. For the development of such systems, coupling with mucoadhesive polymers is highly sought in order to prolong the duration spent at the site of action or absorption. Nasal drug administration is a superior option than oral and parental routes because of the high permeability of the nasal epithelium, rapid drug absorption, avoidance of hepatic first pass metabolism, improved bioavailability of the medication, and fewer adverse effects. adverse local and systemic effects, minimal dosage is required, Patient compliance has increased, direct distribution to the CNS and systemic circulation is available, and self-medication. The development of gastric ulcers can be prevented. Recent evidence indicates that many medications have greater oral bioavailability than nasal bioavailability. So, the focus of this review is on nasal drugs. Administration, various nasal architecture and physiology characteristics, the method of nasal absorption, and benefits, Evaluations of in situ gels' composition, use, and advantages and disadvantages. Keywords: Nasal formulation, sustained drug administration, mucoadhesive drug delivery system, and in-situ nasal gelation