Early diagnosis by genetic analysis of differentiated thyroid cancer metastases in small lymph nodes
- Franco Arturi
- Diego Russo
- Dario Giuffrida
- Antonio Ippolito
- Nicola Perrotti
- Riccardo Vigneri
- Sebastiano Filetti
Publication date
January 1997
DOI Publisher
The Endocrine Society ISSN
0021-972X Citation count (estimate)
139Abstract
We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diameter by the amplification of thyroid specific transcripts TSH-receptor and thyroglobulin. A 100% correspondence with the histopathological diagnosis was observed in the 41/46 nodes (89%) in which an adequate sample was obtained at fine needle aspiration. The genetic analysis resulted more sensitive and accurate than both the cytological analysis (28% inadequate samples, 17% false negative diagnoses) and the thyroglobulin measurement in the aspirates (39% false negatives). The PCR-based genetic analysis may provide a useful tool for diagnosis and follow-up of thyroid cancer
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