Polyamines such as spermine, spermidine and putrescine are necessary for cell proliferation and are detected at higher concentrations in most tumor tissues, compared to normal tissues. The amine oxidase enzymes can generate cytotoxic products such as hydrogen peroxide and aldehydes from these polyamines. This study investigates the mechanisms of cell death in B16-F0 mouse melanoma tumor cells exposed to bovine serum amine oxidase and exogenous spermine. The bovine serum amine oxidase/spermine enzymatic system induced inhibition of cell proliferation in B16-F0 melanoma cells and cell death by both apoptotic and necrotic processes. Bovine serum amine oxidase or spermine, alone, did not induce cytotoxicity or cell death by apoptosis, indicatin...
Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extrac...
It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than th...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. If they accumulat...
Bovine serum amine oxidase (BSAO) oxidatively deaminates polyamines containing primary amine groups,...
AbstractIn situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent appro...
Background The polyamines spermine, spermidine and putrescine are ubiquitous cell components and re...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. These molecules a...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. These molecules a...
Multidrug resistance (MDR) has been studied extensively because it is one of major problems in cance...
Amine oxidases, which contribute to the regulation of polyamine levels, catalyze the oxidative deami...
Spermine oxidase (SMO) is a FAD-containing enzyme while bovine serum amine-oxidase (BSAO) is a coppe...
In situ formation of cytotoxic polyamine metabolites by an enzyme-catalyzed reaction is a recent app...
Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be biological reg...
Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be biological reg...
In tumours, polyamines and amine oxidases increase as compared to normal tissues. Cytotoxicity induc...
Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extrac...
It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than th...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. If they accumulat...
Bovine serum amine oxidase (BSAO) oxidatively deaminates polyamines containing primary amine groups,...
AbstractIn situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent appro...
Background The polyamines spermine, spermidine and putrescine are ubiquitous cell components and re...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. These molecules a...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. These molecules a...
Multidrug resistance (MDR) has been studied extensively because it is one of major problems in cance...
Amine oxidases, which contribute to the regulation of polyamine levels, catalyze the oxidative deami...
Spermine oxidase (SMO) is a FAD-containing enzyme while bovine serum amine-oxidase (BSAO) is a coppe...
In situ formation of cytotoxic polyamine metabolites by an enzyme-catalyzed reaction is a recent app...
Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be biological reg...
Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be biological reg...
In tumours, polyamines and amine oxidases increase as compared to normal tissues. Cytotoxicity induc...
Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extrac...
It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than th...
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. If they accumulat...