Biological activity of antitumoural MGBG: The structural variable
- M.P.M. Marques
- F.P.S.C. Gil
- R. Calheiros
- V. Battaglia
- A.M. Brunati
- Enzo Agostinelli
- A. Toninello
Publication date
January 2008
DOI Publisher
Springer Science and Business Media LLCAbstract
The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations. © 2007 Springer-Verlag
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