Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patients by triggering terminal differentiation of neoplastic cells. RA-sensitivity in APL is mediated by its oncogenic protein, which results from the recombination of the PML and the RA receptor (RAR) genes (PML/RAR fusion protein). Ectopic expression of PML/RARinto haemopoietic cell lines results in increased response to RA-induced differentiation. By structure-function analysis of PML/RAR-mediated RA-differentiation, we demonstrated that fusion of PML and RAR sequences and integrity of the PML dimerization domain and of the RAR DNA binding region are required for the effect of PML/RAR on RA-differentiation. Indeed, direct fusion of the PML dim...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
The t(15;17) chromosomal translocation, specific for acute promyelocytic leukemia (APL), fuses the P...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growt...
The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growt...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
The t(15;17) chromosomal translocation, specific for acute promyelocytic leukemia (APL), fuses the P...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patien...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
International audienceWe report here that the fusion of PML, a nuclear protein defined by the t(15;1...
The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growt...
The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growt...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
International audienceThe t(15;17) chromosomal translocation, specific for acute promyelocytic leuke...
The t(15;17) chromosomal translocation, specific for acute promyelocytic leukemia (APL), fuses the P...