Critical Analysis of the Epistemology of Science (Theory of Knowledge and Scientific Methods) aims to realize the development of Islamic education in Indonesia, as a solution in answering the Challenges of Science and Scientific Methods in Era 4.0. So that in this study it is necessary to uncover and explore the views of Islamic reformers in responding to the Challenges of Science and Scientific Methods in Era 4.0. this study concluded that in terms of realizing the development of Islamic education in Indonesia, as a solution in answering the Challenges of Science and Scientific Methods in Era 4.0, it is necessary to adapt to the development of the existing era, and need renewable science, this is because science and methods Scientific rese...