The frequencies of Low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence of malaria. These "deficiency" alleles are thought to provide reduced risk from infection by the Plasmodium parasite and are maintained at high frequency despite the hemopathologies that they cause. Haplotype analysis of "A-" and "Med" mutations at this Locus indicates that they have evolved independently and have increased in frequency at a rate that is too rapid to be explained by random genetic drift. Statistical modeling indicates that the A- allele arose within the past 3840 to 11,760 years and the Med allele arose within the past 1600 to 6640 years. These results support the hypothesis that malaria has had a...
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selec...
Many human genetic associations with resistance to malaria have been reported, but few have been rel...
G6PD deficiency is a common hemolytic genetic disorder, particularly in the areas endemic to malaria...
The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly co...
Some mutations at the gene coding for glucose-6-phosphate dehydrogenase (G6PD) cause a clinical cond...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common heritable trait whose prevalence mirro...
Glucose-6-phosphate dehydrogenase (G6PD) mutations that result in reduced enzyme activity have been ...
G6PD deficiency is believed to confer protection against Plasmodium falciparum malaria, but it has p...
Glucose-6-phosphate dehydrogenase (G6PD) mutations that result in reduced enzyme activity have been ...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmod...
Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection fro...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency—the most common known enzymopathy— is associated...
Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection fro...
Many human genetic associations with resistance to malaria have been reported, but few have been rel...
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selec...
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selec...
Many human genetic associations with resistance to malaria have been reported, but few have been rel...
G6PD deficiency is a common hemolytic genetic disorder, particularly in the areas endemic to malaria...
The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly co...
Some mutations at the gene coding for glucose-6-phosphate dehydrogenase (G6PD) cause a clinical cond...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common heritable trait whose prevalence mirro...
Glucose-6-phosphate dehydrogenase (G6PD) mutations that result in reduced enzyme activity have been ...
G6PD deficiency is believed to confer protection against Plasmodium falciparum malaria, but it has p...
Glucose-6-phosphate dehydrogenase (G6PD) mutations that result in reduced enzyme activity have been ...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmod...
Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection fro...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency—the most common known enzymopathy— is associated...
Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection fro...
Many human genetic associations with resistance to malaria have been reported, but few have been rel...
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selec...
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selec...
Many human genetic associations with resistance to malaria have been reported, but few have been rel...
G6PD deficiency is a common hemolytic genetic disorder, particularly in the areas endemic to malaria...