Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL-1/AF4 positive acute lymphoblastic leukemia
- CIMINO G
- ELIA L
- RIVOLTA A
- ET AL.
- G. ALIMENA
DOIAbstract
In this study we used reverse transcriptase-polymerase chain reaction (RT-PCR) for the longitudinal monitoring of minimal residual disease in 12 patients with All-1/AF-4 positive ALL. Of these, seven also showed at presentation a typical t(4;11) cytogenetic translocation. Seven patients were infants <18 months of age and five were adults. Eleven patients were treated with high-dose intensive induction and consolidation chemotherapy without bone marrow transplantation and one received conservative treatment due to poor performance status. Three had resistant disease, four relapsed within 12 months after achieving complete remission, and five are in continuous complete remission (CCR) at 32, 39, 52, 53 and 61 months from diagnosis, respective...
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