Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration
- Bonthrone, Alexandra F
- Stegeman, Raymond
- Feldmann, Maria
- Claessens, Nathalie H P
- Nijman, Maaike
- Jansen, Nicolaas J G
- Nijman, Joppe
- Groenendaal, Floris
- de Vries, Linda S
- Benders, Manon J N L
- Haas, Felix
- Bekker, Mirielle N
- Logeswaran, Thushiha
- Reich, Bettina
- Kottke, Raimund
- Hagmann, Cornelia
- Latal, Beatrice
- Dave, Hitendu
- Simpson, John
- Pushparajah, Kuberan
- Austin, Conal
- Kelly, Christopher J
- Arulkumaran, Sophie
- Rutherford, Mary A
- Counsell, Serena J
- Knirsch, Walter
- Breur, Johannes M P J
DOIAbstract
Background: Infants with congenital heart disease are at risk of brain injury and impaired neurodevelopment. The aim was to investigate risk factors for perioperative brain lesions in infants with congenital heart disease. Methods: Infants with transposition of the great arteries, single ventricle physiology, and left ventricular outflow tract and/or aortic arch obstruction undergoing cardiac surgery <6 weeks after birth from 3 European cohorts (Utrecht, Zurich, and London) were combined. Brain lesions were scored on preoperative (transposition of the great arteries N=104; single ventricle physiology N=35; and left ventricular outflow tract and/or aortic arch obstruction N=41) and postoperative (transposition of the great arteries N=88; ...
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