Sleep disorders in Parkinson’s disease

Parkinson’s Disease (PD) is a neurodegenerative disorder characterised by motor and non-motor features. Sleep disruption, including REM-sleep behaviour disorder and circadian rhythm dysfunction, is a well-recognised prodromal aspect of PD, although other features such as restless leg syndrome and other physical factors may contribute. Treatment of PD remains challenging due to the multifactorial nature of the disorder and requires a holistic approach. Improved understanding of central causes may be key to developing novel, effective and targeted treatments. In this month’s journal club, we first review the association between alpha-synuclein in CSF and sleep disorders in prodromal and established PD. Secondly, we explore the role of Diffusion Tensor Imaging in assessing the glymphatic system in a similar cohort comparison. Finally, we will appraise the efficacy of Nabilone as a possible new therapeutic option for sleep disturbance in patients with established PD