The role of male factor in pregnancy loss

Maternal and child health is recognized as a priority in healthcare. Miscarriage is the most common complication of the gestational period. Effectively solving the problem of reproductive losses is possible only at the stage of pregravid preparation of a married couple. Objective. To assess the participation of the male factor in studies of spermogram and cytokine profile in men. Materials and methods. A survey of 471 men from couples with fetal loss syndrome was conducted. The control group consists of 177 men from couples without reproductive losses. All patients underwent an andrological examination, including the assessment of sexual status with the determination of the volume and consistency of the testicles, digital rectal examination, questionnaires, which allow to assess the androgen status and sexual function. Examination for sexually transmitted infections was carried out according to generally accepted standards. Results. In men of the main groups, a statistically significant decrease in the total sperm motility, as well as the number of spermatozoa with progressive movement, was found. A significant decrease in the level of citric acid was recorded, which may indicate a significant inhibition of prostate function. During the examination of men, the incidence of pathospermia was 89% of cases. The leading causative factor of pathospermia is genital tract infection. Conclusion. In existing practice, the importance of sperm of men who have had a viral and chlamydial infection of the genital tract, as a source of infection of the sexual partner and the cause of reproductive loss, is underestimated. With true infectious genesis, there is no difference between spontaneous and habitual miscarriage, if the basis is a viral infection or a viral-bacterial association. © 2020, Media Sphera Publishing Group. All rights reserved