Synthesis of new [γ-(Aryl)pyridino]dibenzo-27,28-diazacrownophanes containing two pyridine rings
- Anh L.T.
- Huyen N.T.T.
- Tam P.T.T.
- Dat N.T.
- Hieu T.H.
- Van T.T.T.
- Hanh L.T.M.
- Soldatenkov A.T.
- Wodajo A.T.
DOI Publisher
Ivanovo State University of Chemistry and TechnologyAbstract
In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyri-dine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs. © ISUCT Publishing
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