Synthesis of Functionalized Bicyclic Compounds Based on 2-(1-Arylethylidene)malononitriles
- Naghiyev F.N.
- Mamedov I.G.
- Asadov K.A.
- Dorovatovskii P.V.
- Khrustalev V.N.
- Maharramov A.M.
DOI Publisher
Pleiades Publishing LtdAbstract
New tetrahydroisoquinoline-5,7-dicarbonitrile derivatives have been synthesized by piperazine hydrate-catalyzed reaction of acetoacetanilide with 2-(1-arylethylidene)malononitriles (Knoevenagel condensation products of acetophenones and malononitrile) in aqueous ethanol at room temperature. The product structure was confirmed by NMR spectra and X-ray analysis of 1,6-diamino-4a-methyl-3-oxo-2,8-diphenyl-2,3,4,4a-tetrahydroisoquinoline-5,7-dicarbonitrile. © 2019, Pleiades Publishing, Ltd
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