Intramolecular cascade annulation triggered by rhodium(III)catalyzed sequential C(sp 2 )–H activation and C(sp 3 )–H amination

Song L.
Tian G.
Van Der Eycken J.
Van Der Eycken E.V.

DOI

10.3762/bjoc.15.52

Publisher

Beilstein Institut

Abstract

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp 2 )–H activation and C(sp 3 )–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance. © 2019 Song et al

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Intramolecular cascade annulation triggered by rhodium(III)catalyzed sequential C(sp 2 )–H activation and C(sp 3 )–H amination

Abstract

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Intramolecular cascade annulation triggered by rhodium(III)catalyzed sequential C(sp 2 )–H activation and C(sp 3 )–H amination

Abstract

Extracted data

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