Protective properties of synthetic peptides of outer meningococcal membrane
- Kotel'nikova O.V.
- Chibiskova O.V.
- Nesmeyanov V.A.
- Alliluev A.P.
- Vol'pina O.V.
- Koroev D.O.
- Zhmak M.N.
- Titova M.A.
- Ivanov V.T.
DOI Publisher
Springer Science and Business Media LLCAbstract
Peptide fragments of conservative sites of PorA, OpaB, and NspA proteins of the outer membrane of serogroup B meningococci were synthesized. These peptides caused a pronounced protective effect in immunized mice infected with virulent homologous and heterologous strains of serogroups B and A meningococci. The protective effect appreciably increased, if the studied peptides were associated in a polycomponent preparation, which can be used in the construction of meningococcal bivalent B+A vaccine. © Springer Science+Business Media, Inc. 2005
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