Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation
- Kalinina E.V.
- Berezov T.T.
- Shtil A.A.
- Chernov N.N.
- Glazunova V.A.
- Novichkova M.D.
- Nurmuradov N.K.
DOI Publisher
Springer Science and Business Media LLCAbstract
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells. © 2012 Springer Science+Business Media New York
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