Synthesis of 1,2,5-trimethyl-4-ethoxycarbonylmethyl-4-hydroxypiperidine and its homologs

1,2,5-Trimethyl-4-ethoxycarbonylmethyl-4-hydroxypiperidine was obtained by the Reformatsky reaction between 1,2,5-trimethyl-4-piperidone and ethyl bromoacetate. Homologs were obtained from the same piperidone and ethyl α-bromo-α-alkylacetates. Some further reactions of these hydroxypiperidines were studied. © 1971 Consultants Bureau