The outbreak of the Covid-19 crisis has triggered political tensions involving different levels of government. Italy constitutes a paradigmatic example of such problems. The powers assigned to regional presidents as a result of the dynamics of presidentialization make them key players in Italy’s fragmented multilevel system. The article aims to demonstrate that the conflict between national and regional governments during the pandemic has been based mainly on polity reasons, that is regional governments’ ambition to strengthen their autonomy, rather than on policy arguments. The Covid-19 crisis in Italy has taken the form of an intergovernmental conflict over the balance of authority between central and regional governments. This state of a...