Illness Severity in Hospitalized Influenza Patients by Virus Type and Subtype, Spain, 2010-2017

Delgado-Sanz, Concepcion
Mazagatos, Clara
Oliva Dominguez, Jesus Angel
Gherasim, Alin Manuel
Larrauri, Amparo

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Publication date

February 2020

DOI

10.3201/eid2602.181732

Publisher

Centers for Disease Control and Prevention (CDC)

Journal

Emerging Infectious Diseases

Language

English

Abstract

We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influe...