Combining the selectivity of G-quadruplex (G4) ligands with the spatial and temporal control of photochemistry is an emerging strategy to elucidate the biological relevance of these structures. In this work, we developed six novel V-shaped G4 ligands that can, upon irradiation, form stable covalent adducts with G4 structures via the reactive intermediate, quinone methide (QM). We thoroughly investigated the photochemical properties of the ligands and their ability to generate QMs. Subsequently, we analyzed their specificity for various topologies of G4 and discovered a preferential binding towards the human telomeric sequence. Finally, we tested the ligand ability to act as photochemical alkylating agents, identifying the covalent adducts w...
The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of potential applicatio...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
International audienceLight-activated functional materials capable of remote control over duplex and...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphth...
Light-activated functional materials capable of remote control over duplex and G-quadruplex (G4) nuc...
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate ...
The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of potential applicatio...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
International audienceCombining the selectivity of G-quadruplex (G4) ligands with the spatial and te...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
International audienceLight-activated functional materials capable of remote control over duplex and...
Guanine-rich DNA sequences can fold into non-canonical nucleic acid structures called G-quadruplexes...
We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphth...
Light-activated functional materials capable of remote control over duplex and G-quadruplex (G4) nuc...
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate ...
The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of potential applicatio...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...
We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing...