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We present ZodiPy, a modern and easy-to-use Python package for modeling the zodiacal emission seen by an arbitrary Solar System observer, which can be used for the removal of both thermal emission and scattered sunlight from interplanetary dust in astrophysical data. The code implements the COBE Diffuse Infrared Background Experiment (DIRBE) interplanetary dust model and the Planck extension, which allows for zodiacal emission predictions at infrared wavelengths in the 1.25–240 µm range and at microwave frequencies in the 30–857 GHz range. The predicted zodiacal emission may be extrapolated to frequencies and wavelengths not covered by the built-in models to produce forecasts for future experiments. ZodiPy attempts to enable the development of new interplanetary dust models by providing the community with an easy-to-use interface for testing both current and future models. We demonstrate how the software can be used by creating simulated zodiacal emission timestreams for the DIRBE experiment and show that these agree with corresponding timestreams produced with the DIRBE Zodiacal Light Prediction Software. We also make binned maps of the zodiacal emission as predicted to be observed by DIRBE and compare them with the DIRBE calibrated individual observations (CIO)