Carbohydrates are one of the most abundant and important classes of biomolecules. The variety in their structures makes them valuable carriers that can improve the pharmaceutical phase, pharmacokinetics and pharmacodynamics of well-known drugs. D-galactose is a simple, naturally occurring monosaccharide sugar that has been extensively studied for use as a carrier and has proven to be valuable in this role. With the aim of validating the galactose-prodrug approach, we have investigated the galactosylated prodrugs ibuprofen, ketoprofen, flurbiprofen and indomethacin, which we have named IbuGAL, OkyGAL, FluGAL and IndoGAL, respectively. Their physicochemical profiles in terms of lipophilicity, solubility and chemical stability have been evalua...
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release ...
280-283Topical delivery of ibuprofen directly to the site of inflammation can overcome gastrointes...
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activit...
Carbohydrates are one of the most abundant and important classes of biomolecules. The variety in the...
Although ketorolac is one of the most potent anti-inflammatory and analgesic drugs, its use has been...
Paracetamol has been one of the most commonly used and prescribed analgesic drugs for more than a hu...
Aceclofenac is a popular analgesic, antipyretic, and nonsteroidal anti-inflammatory drug (NSAID) use...
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adv...
Zaman Ashraf,1,2 Alamgeer,3 Munazza Kanwal,1 Mubashir Hassan,2 Sahar Abdullah,3 Mamuna Waheed,3 Hase...
The effects of natural and synthetic galactooligosaccharides (GOS) on inflammation were explored by ...
The aim of this study was to investigate the potential of prodrugs of some non-steroidal anti-inflam...
Etodolac, a nonsteroidal antiinflammatory drug, widely used in arthritis is associated with gastric ...
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is c...
N-Palmitoylethanolamide (PEA) is emerging as a novel therapeutic agent in the treatment of neuropath...
AbstractThe current work envisages synthesis of an ester prodrug of flurbiprofen whereby its carboxy...
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release ...
280-283Topical delivery of ibuprofen directly to the site of inflammation can overcome gastrointes...
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activit...
Carbohydrates are one of the most abundant and important classes of biomolecules. The variety in the...
Although ketorolac is one of the most potent anti-inflammatory and analgesic drugs, its use has been...
Paracetamol has been one of the most commonly used and prescribed analgesic drugs for more than a hu...
Aceclofenac is a popular analgesic, antipyretic, and nonsteroidal anti-inflammatory drug (NSAID) use...
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adv...
Zaman Ashraf,1,2 Alamgeer,3 Munazza Kanwal,1 Mubashir Hassan,2 Sahar Abdullah,3 Mamuna Waheed,3 Hase...
The effects of natural and synthetic galactooligosaccharides (GOS) on inflammation were explored by ...
The aim of this study was to investigate the potential of prodrugs of some non-steroidal anti-inflam...
Etodolac, a nonsteroidal antiinflammatory drug, widely used in arthritis is associated with gastric ...
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is c...
N-Palmitoylethanolamide (PEA) is emerging as a novel therapeutic agent in the treatment of neuropath...
AbstractThe current work envisages synthesis of an ester prodrug of flurbiprofen whereby its carboxy...
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release ...
280-283Topical delivery of ibuprofen directly to the site of inflammation can overcome gastrointes...
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activit...