Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the bacteria Yersinia pestis, is currently treated effectively with antibiotics. However, in the case of multidrug-resistant (MDR) bacteria, alternative treatments are required. Bacteriophage (phage) therapy has shown efficient antibacterial activity in various experimental animal models and in human patients infected with different MDR pathogens. Here, we evaluated the efficiency of фA1122 and PST phage therapy, alone or in combination with second-line antibiotics, using a well-established mouse model of pneumonic plague. Phage treatment significantly delayed mortality and limited bacterial proliferation in the lungs. Howev...
Abstract Background In 1982 Smith and Huggins showed that bacteriophages could be at least as effect...
Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat ...
With the emerging threat of infections caused by multidrug resistant bacteria, phages have been reco...
are routinely used for plague diagnostics and could be an alternative to antibiotics in case of dru...
Background: Pseudomonas aeruginosa (PsA) is a common etiology of bacteria-mediated lower respiratory...
International audienceSupported by years of clinical use in some countries and more recently by lite...
Drug resistance is the major cause of increase in morbidity and mortality in neonates. One thousand ...
International audienceAntibiotic-resistant bacteria threaten life worldwide. Although new antibiotic...
BACKGROUND: Bacteriophages specific for Yersinia pestis are routinely used for plague diagnostics an...
Bacteraemia can be caused by Acinetobacter baumannii (A. baumannii), with clinical manifestations ra...
The injudicious use of antibiotics not only in medicine but also to promote the growth of farm anima...
With escalating resistance to antibiotics, there is an urgent need to develop alternative therapies ...
The evolution of antibiotic resistance in bacteria is a global concern and the use of bacteriophages...
International audienceThe alarming diffusion of multidrug-resistant (MDR) bacterial strains requires...
Infections caused by multidrug-resistant (MDR) bacteria have highlighted the importance of the devel...
Abstract Background In 1982 Smith and Huggins showed that bacteriophages could be at least as effect...
Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat ...
With the emerging threat of infections caused by multidrug resistant bacteria, phages have been reco...
are routinely used for plague diagnostics and could be an alternative to antibiotics in case of dru...
Background: Pseudomonas aeruginosa (PsA) is a common etiology of bacteria-mediated lower respiratory...
International audienceSupported by years of clinical use in some countries and more recently by lite...
Drug resistance is the major cause of increase in morbidity and mortality in neonates. One thousand ...
International audienceAntibiotic-resistant bacteria threaten life worldwide. Although new antibiotic...
BACKGROUND: Bacteriophages specific for Yersinia pestis are routinely used for plague diagnostics an...
Bacteraemia can be caused by Acinetobacter baumannii (A. baumannii), with clinical manifestations ra...
The injudicious use of antibiotics not only in medicine but also to promote the growth of farm anima...
With escalating resistance to antibiotics, there is an urgent need to develop alternative therapies ...
The evolution of antibiotic resistance in bacteria is a global concern and the use of bacteriophages...
International audienceThe alarming diffusion of multidrug-resistant (MDR) bacterial strains requires...
Infections caused by multidrug-resistant (MDR) bacteria have highlighted the importance of the devel...
Abstract Background In 1982 Smith and Huggins showed that bacteriophages could be at least as effect...
Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat ...
With the emerging threat of infections caused by multidrug resistant bacteria, phages have been reco...