In this paper, we refer to a real case study of an industrial partner recently committed to its project on the design of a multi-unit and multi-product manufacturing system. Although the considered problem refers to an actual complex manufacturing system, it can be theoretically classified as a union of two key problems that need to be solved during the transfer line design stage: the transfer line balancing problem (TLBP) and the buffer allocation problem (BAP). As two closely related problems, TLBP and BAP usually have similar optimizing directions and share the same purpose: finding a balance between the performance of the transfer line system as well as minimizing investment costs. These problems are usually solved sequentially, but thi...