Base-selective access to highly functionalized heterocycles from multicomponent Ugi adducts

Selection of the appropriate base in Ugi/post-condensation sequences allows the selective syntheses of different ring-size functionalized lactams. The developed methodology uses inexpensive bases under mild and non-sensitive conditions leading to the facile generation of molecular diversity from simple synthons.Funding from Consejería de Educación de la Junta de Castilla y León and European Regional Development Fund (ERDF) (project BU075G19 and project BU067P20) and MCIN/AEI/10.13039/501100011033 [grant PID2020-117610RB-I00] is gratefully acknowledged. B. G.-S. and I. C.-B. thank Consejería de Educación de la Junta de Castilla y León, European Social Fund (ESF) and ERDF for their predoctoral (B. G.-S) and postdoctoral (I. C.-B.) contracts