Synthesis, folding, and structural maturation of proteins occur in the endoplasmic reticulum (ER). Accumulation of misfolded or unfolded proteins in the ER lumen contributes to the induction of ER stress and activation of the unfolded protein response (UPR) signaling pathway. Under ER stress, the UPR tries to maintain cellular homeostasis through different pathways, including the inositol-requiring enzyme 1 alpha (IRE1α)-dependent ones. IRE1α is located in an ER membrane, and it is evolutionarily the oldest UPR sensor. Activation of IRE1α via ER stress triggers the formation of the spliced form of XBP1 (XBP1s), which has been linked to a pro-survival effect in cancer cells. The role of IRE1α is critical for blood cancer cells, and it was fo...
International audienceIRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of th...
The endoplasmic reticulum (ER) responds to the accumulation of misfolded proteins in its lumen (term...
International audienceTumor cells are often exposed to intrinsic and external factors that alter pro...
Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by...
International audienceIRE1α is one of the three ER transmembrane transducers of the Unfolded Protein...
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stre...
International audienceThe unfolded protein response (UPR) was originally identified as a signaling n...
International audienceThe ability of a tumor cell to cope with environmental and intracellular stres...
International audienceThe Unfolded Protein response is an adaptive pathway triggered upon alteration...
X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a p...
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein ...
IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein res...
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolut...
International audienceIRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of th...
The endoplasmic reticulum (ER) responds to the accumulation of misfolded proteins in its lumen (term...
International audienceTumor cells are often exposed to intrinsic and external factors that alter pro...
Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by...
International audienceIRE1α is one of the three ER transmembrane transducers of the Unfolded Protein...
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stre...
International audienceThe unfolded protein response (UPR) was originally identified as a signaling n...
International audienceThe ability of a tumor cell to cope with environmental and intracellular stres...
International audienceThe Unfolded Protein response is an adaptive pathway triggered upon alteration...
X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a p...
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein ...
IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein res...
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolut...
International audienceIRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of th...
The endoplasmic reticulum (ER) responds to the accumulation of misfolded proteins in its lumen (term...
International audienceTumor cells are often exposed to intrinsic and external factors that alter pro...