Transcribed Ultraconserved Regions in Cancer

Myron K. Gibert
Aditya Sarkar
Bilhan Chagari
Christian Roig-Laboy
Shekhar Saha
Sylwia Bednarek
Benjamin Kefas
Farina Hanif
Kadie Hudson
Collin Dube
Ying Zhang
Roger Abounader

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Publication date

May 2022

DOI

10.3390/cells11101684

Publisher

MDPI AG

Journal

Cells

Abstract

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives