Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
- Kuhle, J
- Disanto, G.
- Dobson, R.
- Adiutori, R.
- Bianchi, L.
- Topping, J.
- Bestwick, J. P.
- Meier, U. C.
- Marta, M.
- Dalla Costa, G.
- Runia, T.
- Evdoshenko, E.
- Lazareva, N.
- Thouvenot, E.
- IAFFALDANO, PIETRO
- Direnzo, V.
- Khademi, M.
- Piehl, F.
- Comabella, M.
- Sombekke, M.
- Killestein, J.
- Hegen, H.
- Rauch, S.
- Dalfonso, S.
- Alvarez Cermeño, J. C.
- Kleinová, P.
- Horáková, D.
- Roesler, R.
- Lauda, F.
- Llufriu, S.
- Avsar, T.
- Uygunoglu, U.
- Altintas, A.
- Saip, S.
- Menge, T.
- Rajda, C.
- Bergamaschi, R.
- Moll, N.
- Khalil, M.
- Marignier, R.
- Dujmovic, I.
- Larsson, H.
- Malmestrom, C.
- Scarpini, E.
- Fenoglio, C.
- Wergeland, S.
- Laroni, A.
- Annibali, V.
- Romano, S.
- Martínez, A. D.
- Carra, A.
- Salvetti, M.
- Uccelli, A.
- Torkildsen, Ø.
- Myhr, K. M.
- Galimberti, D.
- Rejdak, K.
- Lycke, J.
- Frederiksen, J. L.
- Drulovic, J.
- Confavreux, C.
- Brassat, D.
- Enzinger, C.
- Fuchs, S.
- Bosca, I.
- Pelletier, J.
- Picard, C.
- Colombo, E.
- Franciotta, D.
- Derfuss, T.
- Lindberg, R. L. P.
- Yaldizli, Ö.
- Vécsei, L.
- Kieseier, B. C.
- Hartung, H. P.
- Villoslada, P.
- Siva, A.
- Saiz, A.
- Tumani, H.
- Havrdová, E.
- Villar, L. M.
- Leone, M.
- Barizzone, N.
- Deisenhammer, F.
- Teunissen, C.
- Montalban, X.
- Tintoré, M.
- Olsson, T.
- TROIANO, Maria
- Lehmann, S.
- Castelnovo, G.
- Lapin, S.
- Hintzen, R.
- Kappos, L.
- Furlan, R.
- Martinelli, V.
- Comi, G.
- Ramagopalan, S. V.
- Giovannoni, G.
DOIAbstract
Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. Results: At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion i...
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