G protein-coupled receptors (GPCRs) are intricately involved in the conversion of extracellular feedback to intracellular responses. These specialized receptors possess a crucial role in neurological and psychiatric disorders. Most nonsensory GPCRs are active in almost 90% of complex brain functions. At the time of receptor phosphorylation, a GPCR pathway is essentially activated through a G protein signaling mechanism via a G protein-coupled receptor kinase (GRK). Dopamine, an important neurotransmitter, is primarily involved in the pathophysiology of several CNS disorders; for instance, bipolar disorder, schizophrenia, Parkinson’s disease, and ADHD. Since dopamine, acetylcholine, and glutamate are potent neuropharmacological targets, dopa...
Metabotropic receptors are responsible for so-called ‘slow synaptic transmission’ and mediate the ef...
G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the huma...
Schizophrenia remains a sizable socio-economic burden that continues to be treated with therapeutics...
Abstract: G protein-coupled receptors (GPCRs) are the most common targets of the neuropharmacologica...
The G protein-coupled receptor (GPCR) family is among the most druggable families in the human prote...
A systems view of G protein-coupled receptor (GPCR) signaling in its native environment is central t...
The G protein-coupled receptor (GPCR) family is among the most druggable families in the human prote...
G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane domain receptors that ...
G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane domain receptors that ...
Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and ...
G protein-coupled receptors (GPCRs) are the most common targets of the neuropharmacological drugs in...
Abstract: G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in es...
AbstractG protein coupled receptors (GPCRs) represent the most important targets in modern pharmacol...
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic li...
Abstract Background Understanding the mechanisms, activated and inhibited pathways as well as other ...
Metabotropic receptors are responsible for so-called ‘slow synaptic transmission’ and mediate the ef...
G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the huma...
Schizophrenia remains a sizable socio-economic burden that continues to be treated with therapeutics...
Abstract: G protein-coupled receptors (GPCRs) are the most common targets of the neuropharmacologica...
The G protein-coupled receptor (GPCR) family is among the most druggable families in the human prote...
A systems view of G protein-coupled receptor (GPCR) signaling in its native environment is central t...
The G protein-coupled receptor (GPCR) family is among the most druggable families in the human prote...
G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane domain receptors that ...
G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane domain receptors that ...
Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and ...
G protein-coupled receptors (GPCRs) are the most common targets of the neuropharmacological drugs in...
Abstract: G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in es...
AbstractG protein coupled receptors (GPCRs) represent the most important targets in modern pharmacol...
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic li...
Abstract Background Understanding the mechanisms, activated and inhibited pathways as well as other ...
Metabotropic receptors are responsible for so-called ‘slow synaptic transmission’ and mediate the ef...
G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the huma...
Schizophrenia remains a sizable socio-economic burden that continues to be treated with therapeutics...