Understanding the function of E3 ligases without genetic manipulation has proven to be a challenge. E3 ligases are responsible for numerous biological processes although very little is known about them. The unique approach of synthesising activity or chemical probes in the biochemical industry has emerged over the years. in this study we will explore the foundations of synthesising an activity probe that focuses primarily on the E3 ligase. Using x-ray crystallography, we were able to identify potential binding sites in which the activity probe could anchor onto before labelling the protein by nucleophilic attack. Prior knowledge of the relationship of thalidomide and E3 ligase Cereblon , meant that thalidomide was a suitable candidate for...
Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new mod...
The covalent attachment of ubiquitin (Ub) to internal lysine residue(s) of a substrate protein, a pr...
Redirecting E3 ligases to neo-substrates leading to their proteasomal disassembly, known as targeted...
Repurposing E3 ubiquitin ligases for targeted protein degradation via customized molecular glues or ...
Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can b...
Abstract Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination ...
Methods to direct the degradation of protein targets with proximity-inducing molecules that coopt th...
Previously, we reported a new method for intracellular protein labeling in living cells called PRIME...
Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue...
Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can b...
Previously, we reported a new method for intracellular protein labeling in living cells called PRIME...
Ubiquitination is a diverse post-translational modification, involved in a plethora of eukaryotic pr...
Ubiquitination is a key post-translational modification in the regulation of numerous biological pro...
E2 conjugating enzymes are the key catalytic actors in the transfer of ubiquitin, SUMO, and other ub...
Many pharmaceuticals on the market today belong to a large class of natural products called nonribos...
Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new mod...
The covalent attachment of ubiquitin (Ub) to internal lysine residue(s) of a substrate protein, a pr...
Redirecting E3 ligases to neo-substrates leading to their proteasomal disassembly, known as targeted...
Repurposing E3 ubiquitin ligases for targeted protein degradation via customized molecular glues or ...
Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can b...
Abstract Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination ...
Methods to direct the degradation of protein targets with proximity-inducing molecules that coopt th...
Previously, we reported a new method for intracellular protein labeling in living cells called PRIME...
Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue...
Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can b...
Previously, we reported a new method for intracellular protein labeling in living cells called PRIME...
Ubiquitination is a diverse post-translational modification, involved in a plethora of eukaryotic pr...
Ubiquitination is a key post-translational modification in the regulation of numerous biological pro...
E2 conjugating enzymes are the key catalytic actors in the transfer of ubiquitin, SUMO, and other ub...
Many pharmaceuticals on the market today belong to a large class of natural products called nonribos...
Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new mod...
The covalent attachment of ubiquitin (Ub) to internal lysine residue(s) of a substrate protein, a pr...
Redirecting E3 ligases to neo-substrates leading to their proteasomal disassembly, known as targeted...