Combining neuroanatomical features to support diagnosis of fetal alcohol spectrum disorders

International audienceAbstractAim: To identify easily accessible neuroanatomical abnormalities useful for diagnosing fetal alcohol spectrum disorders (FASD) in fetal alcohol syndrome (FAS) but more importantly for the probabilistic diagnosis of non-­syndromic forms (NS-­FASD).Method: We retrospectively collected monocentric data from 52 individuals with FAS, 37 with NS-­FASD, and 94 paired typically developing individuals (6–­20 years, 99 males, 84 females). On brain T1-­weighted magnetic resonance imaging, we measured brain size, corpus callosum length and thicknesses, vermis height, then evaluated vermis foliation (Likert scale). For each parameter, we established variations with age and brain size in comparison individuals (growth and scaling charts), then identified participants with abnormal measurements (