A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)
- Piccinonna S
- Iacobazzi RM
- MARGIOTTA, NICOLA
- DENORA, NUNZIO
- PACIFICO, Concetta
- TRAPANI, Giuseppe
- NATILE, Giovanni
Publication date
January 2013
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
1477-9226 Citation count (estimate)
7Abstract
A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac- [ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein
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