International audienceLithium is the first-line mood stabilizer for the treatment of patients with bipolar disorder. However, its mechanisms of action and transport across the blood–brain barrier remain poorly understood. The contribution of lithium-7 magnetic resonance imaging ($^7$Li MRI) to investigate brain lithium distribution remains limited because of the modest sensitivity of the lithium nucleus and the expected low brain concentrations in humans and animal models. Therefore, we decided to image lithium distribution in the rat brain ex vivo using a turbo-spin-echo imaging sequence at 17.2 T. The estimation of lithium concentrations was performed using a phantom replacement approach accounting for $B_1$ inhomogeneities and differenti...
BACKGROUND: Little is known about the extent of drug entry into developing brain, when administered ...
International audienceBACKGROUND:MRI studies in patients with bipolar disorder have suggested that l...
Despite its narrow therapeutic window, lithium is still regarded as the gold standard comparator and...
International audienceLithium is the first-line mood stabilizer for the treatment of patients with b...
The pharmacokinetics of lithium uptake was measured by Li NMR spectroscopy at 24.83 MHz in vivo in t...
Lithium (Li) is a potent mood stabilizer and displays neuroprotective and neurogenic properties. Des...
Lithium is a major treatment for bipolar disorder and the likelihood of a favourable response may be...
Bipolar disorder is a chronic affective disorder affecting 1 to 3% of the adult population worldwide...
Lithium-induced neurotoxicity may be life threatening. Three patterns have been described, including...
Backgraound. Lithium is widely used in the treatment of mood disorders, but little is known about it...
Le lithium est le traitement de référence du trouble bipolaire. Cependant, il peut être responsable ...
PhD ThesisBipolar disorder is a major mental illness affecting 1% of the world's population and whil...
PhD ThesisThis thesis explores the effects of lithium on the human brain using structural, function...
Lithum salts have been widely used in the treatment of mood disorders, but the mechanism of action i...
The mechanism of action of lithium is still largely unknown. However, recent animal and human studie...
BACKGROUND: Little is known about the extent of drug entry into developing brain, when administered ...
International audienceBACKGROUND:MRI studies in patients with bipolar disorder have suggested that l...
Despite its narrow therapeutic window, lithium is still regarded as the gold standard comparator and...
International audienceLithium is the first-line mood stabilizer for the treatment of patients with b...
The pharmacokinetics of lithium uptake was measured by Li NMR spectroscopy at 24.83 MHz in vivo in t...
Lithium (Li) is a potent mood stabilizer and displays neuroprotective and neurogenic properties. Des...
Lithium is a major treatment for bipolar disorder and the likelihood of a favourable response may be...
Bipolar disorder is a chronic affective disorder affecting 1 to 3% of the adult population worldwide...
Lithium-induced neurotoxicity may be life threatening. Three patterns have been described, including...
Backgraound. Lithium is widely used in the treatment of mood disorders, but little is known about it...
Le lithium est le traitement de référence du trouble bipolaire. Cependant, il peut être responsable ...
PhD ThesisBipolar disorder is a major mental illness affecting 1% of the world's population and whil...
PhD ThesisThis thesis explores the effects of lithium on the human brain using structural, function...
Lithum salts have been widely used in the treatment of mood disorders, but the mechanism of action i...
The mechanism of action of lithium is still largely unknown. However, recent animal and human studie...
BACKGROUND: Little is known about the extent of drug entry into developing brain, when administered ...
International audienceBACKGROUND:MRI studies in patients with bipolar disorder have suggested that l...
Despite its narrow therapeutic window, lithium is still regarded as the gold standard comparator and...