Localization matters in targeted protein degradation

Shah, V.
Đikić, I.

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Publication date

October 2022

DOI

10.1016/j.chembiol.2022.09.006

Publisher

Elsevier BV

Abstract

Many factors influence the efficiency of targeted protein degradation induced by proteolysis targeting chimeras (PROTACs). In this issue of Cell Chemical Biology, Simpson et al. (2022) highlight the impact of subcellular localization. Their study elucidates that the protein of interest exhibits different amenability to PROTAC-mediated degradation at different cellular compartments

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Localization matters in targeted protein degradation

Abstract

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Localization matters in targeted protein degradation

Abstract

Extracted data

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