Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression is sustained by recruitment of a strong tumor microenvironment (TME) mainly composed of cancer-associated fibroblasts (CAFs) able to endorse tumor hallmarks. Increasing evidences demonstrate that exosomes mediate the crosstalk between cancer cells and the TME. We examined TNBC-derived exosomes and their microRNA (miRNA) cargo in activation of normal fibroblasts (NFs) toward CAFs. We demonstrated that TNBC cell-derived exosomes increased NF collagen contraction and migration alongside CAF molecular markers. Exosome-activated fibroblasts promoted the invasion potential of normal breast epithelial cells, as assessed by an organotypic co-culture ...
Triple-negative breast cancer is the most potent metastatic type of breast cancer that can spread to...
Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cance...
The second most pervasive cancer affecting the survival of women across the world is breast cancer. ...
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression ...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They m...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They ma...
Abstract Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-associated...
Stroma-derived exosomal microRNA (exomiR) contributes to tumor progression, however, which remains p...
Exosomes are nanovesicles derived from multiple cell types and could be isolated from various bodily...
SummaryExosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we repo...
Despite many novel therapeutic approaches, breast cancer remains one of the leading cause of cancer ...
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes. Chemoresi...
Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to ...
Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer dea...
Abstract Background Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. ...
Triple-negative breast cancer is the most potent metastatic type of breast cancer that can spread to...
Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cance...
The second most pervasive cancer affecting the survival of women across the world is breast cancer. ...
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression ...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They m...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They ma...
Abstract Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-associated...
Stroma-derived exosomal microRNA (exomiR) contributes to tumor progression, however, which remains p...
Exosomes are nanovesicles derived from multiple cell types and could be isolated from various bodily...
SummaryExosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we repo...
Despite many novel therapeutic approaches, breast cancer remains one of the leading cause of cancer ...
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes. Chemoresi...
Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to ...
Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer dea...
Abstract Background Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. ...
Triple-negative breast cancer is the most potent metastatic type of breast cancer that can spread to...
Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cance...
The second most pervasive cancer affecting the survival of women across the world is breast cancer. ...