Protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes are two emerging targets differently involved in the onset of type 2 diabetes mellitus (T2DM). Diabetes mellitus is a complex disease and is one of the leading causes of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chronic complications. The opportunity to design inhibitors capable to bind orthosteric and allosteric regions of both PTP1B and AR is a promising tool for the discovery of new designed multiple ligands for T2DM treatment. Marine environment offers an enormous pool of chemical structures with uncommon and different structural motifs with a wide range of pharmaceutical applications. Phosph...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and...
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose ...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorde...
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and...
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets ...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...
Type 2 Diabetes is a medical condition involving pathophysiological manifestations of atypical blood...