RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies
- Di Castelnuovo A.
- Costanzo S.
- Antinori A.
- Berselli N.
- Blandi L.
- Bonaccio M.
- Cauda R.
- Gialluisi A.
- Guaraldi G.
- Menicanti L.
- Mennuni M.
- Mussinelli R.
- My I.
- Parruti G.
- Patti G.
- Perlini S.
- Santilli F.
- Signorelli C.
- Stefanini G. G.
- Vergori A.
- Abete P.
- Ageno W.
- Agostoni P.
- Aiello L.
- Al Moghazi S.
- Arboretti R.
- Aucella F.
- Barbieri G.
- Barchitta M.
- Bartoloni A.
- Bonfanti P.
- Cacciatore F.
- Caiano L.
- Carrozzi L.
- Cascio A.
- Castiglione G.
- Cianfrone S.
- Ciccullo A.
- Cingolani A.
- Cipollone F.
- Colomba C.
- Colombo C.
- Cozzi O.
- Crisetti A.
- Crosta F.
- Danzi G. B.
- D'Ardes D.
- de Gaetano Donati K.
- Di Gennaro F.
- Di Tano G.
- D'Offizi G.
- Fusco F. M.
- Gentile I.
- Graziani E.
- Guarnieri G.
- Larizza G.
- Leone A.
- Lio V.
- Lucia M. B.
- Maccagni G.
- Madaro F.
- Maitan S.
- Mancarella S.
- Manuele R.
- Mapelli M.
- Maragna R.
- Marcucci R.
- Maresca G.
- Marongiu S.
- Marotta C.
- Marra L.
- Mastroianni F.
- Mazzitelli M.
- Mengozzi A.
- Menichetti F.
- Meschiari M.
- Milic J.
- Minutolo F.
- Molena B.
- Mussini C.
- Musso M.
- Odone A.
- Olivieri M.
- Palimodde A.
- Pasi E.
- Pesavento R.
- Petri F.
- Pinchera B.
- Pivato C. A.
- Poletti V.
- Ravaglia C.
- Rossato M.
- Rossi M.
- Sabena A.
- Salinaro F.
- Sangiovanni V.
- Sanrocco C.
- Scoppettuolo G.
- Scorzolini L.
- Sgariglia R.
- Simeone P. G.
- Trecarichi E. M.
- Vettor R.
- Vianello A.
- Vinceti M.
- Virano A.
- Vocciante L.
- De Caterina R.
- Iacoviello L.
DOIAbstract
Objective: The hypothesis that been set forward that use of Renin Angiotensin Aldosterone System (RAAS) inhibitors is associated with COVID−19 severity. We set-up a multicenter Italian collaboration (CORIST Project, ClinicalTrials.gov ID: NCT04318418) to retrospectively investigate the relationship between RAAS inhibitors and COVID−19 in-hospital mortality. We also carried out an updated meta-analysis on the relevant studies. Methods: We analyzed 4069 unselected patients with laboratory-confirmed SARS-CoV-2 infection and hospitalized in 34 clinical centers in Italy from February 19, 2020 to May 23, 2020. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received angiotensin-converting–enzyme inh...
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