A hydrophilic olefin Pt(0) complex containing a glucoconjugated 2-iminopyridine ligand: Synthesis, characterization, stereochemistry and biological activity
- Annunziata A.
- Cucciolito M. E.
- Imbimbo P.
- Silipo A.
- Ruffo F.
DOIAbstract
The synthesis of a novel water-soluble Pt(0) complex [Pt(1-gluAc)(dmf)] containing a glucoconjugated 2-iminopyridine ligand and dimethylfumarate is reported. Highly diastereoselectivity leads to the prevalent formation of only one of the possible diasteroisomers, which has been characterized by mono- and bi-dimensional NMR techniques. The anticancer activity of the complex was evaluated against two couples of cell lines, and the IC50 values reveal that it is more cytotoxic than cisplatin but no selective toward cancer cells
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