BACKGROUND: In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes cause a high risk of developing a broad spectrum of cancers. To date, the management of patients with Lynch syndrome has represented a major challenge because of large variations in age at cancer onset. Several factors, including genetic anticipation, have been proposed to explain this phenotypic heterogeneity, but the molecular mechanisms remain unknown. Telomere shortening is a common event in tumorigenesis and also has been observed in different familial cancers. In this study, the authors investigated the possibility of a relation between telomere length and cancer onset in patients with Lynch syndrome. METHODS: The mean telomere length wa...
Telomeres are protein structures that regulate the process of cellular aging and play the role of a ...
Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal...
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an e...
BACKGROUND: In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes c...
In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes cause a high ...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Aberrant telomere length measured in blood has been associated with increased risk of several cancer...
Aberrant telomere length measured in blood has been associated with increased risk of several cancer...
DNA mismatch repair (MMR) deficiency is the hallmark of Lynch syndrome (LS), an autosomal inherited ...
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most cancers, and ...
Lynch syndrome (LS) is an inherited cancer-predisposing disorder caused by germline mutations in the...
Lynch syndrome (LS) is the most common form of inherited predisposition to develop cancer mainly in ...
Impaired chromosome segregation during mitosis, inaccurate DNA damage response and excessive telomer...
Telomeres are protein structures that regulate the process of cellular aging and play the role of a ...
Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal...
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an e...
BACKGROUND: In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes c...
In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes cause a high ...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Telomere length variation has been associated with increased risk of several types of tumors, and te...
Aberrant telomere length measured in blood has been associated with increased risk of several cancer...
Aberrant telomere length measured in blood has been associated with increased risk of several cancer...
DNA mismatch repair (MMR) deficiency is the hallmark of Lynch syndrome (LS), an autosomal inherited ...
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most cancers, and ...
Lynch syndrome (LS) is an inherited cancer-predisposing disorder caused by germline mutations in the...
Lynch syndrome (LS) is the most common form of inherited predisposition to develop cancer mainly in ...
Impaired chromosome segregation during mitosis, inaccurate DNA damage response and excessive telomer...
Telomeres are protein structures that regulate the process of cellular aging and play the role of a ...
Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal...
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an e...