Igf1 for the diagnosis of growth hormone deficiency in children and adolescents: A reappraisal
- Ibba A.
- Corrias F.
- Guzzetti C.
- Casula L.
- Salerno M.
- Di Iorgi N.
- Tornese G.
- Patti G.
- Radetti G.
- Maghnie M.
- Cappa M.
- Loche S.
DOIAbstract
A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/ genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1 <6, G2 6 <9, G3 9 <12, G4 ≥12) and to pubertal status. Serum IGFI was measured by the same chemiluminescence assay in all samples and expressed as age-and sex-based SDS. Receiver operating characteristic (ROC) analysis was used to ...
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