Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass and angioplasty procedures, causing the failure of venous grafts or restenosis of the reopened vessel. Investigation into the mechanisms underlying the process of VSM cellular proliferation has provided evidence that intracellular signaling mechanisms triggered by extracellular hormonal factors acting through G protein-coupled receptors, can mediate and sustain this pathological process. Inhibition of common pathways of G protein-coupled receptor signaling has recently proven effective in preventing VSM cellular activation and proliferation. In particular, inhibition of the G beta gamma-mediated mitogen-activated protein (MAP) kinase signali...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Proliferation of vascular smooth muscle (VSM) severely affects the outcome of coronary artery bypass...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedure...
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogen...