The senescence-accelerated mouse (SAM) is a murine model of accelerated senescence that was established using phenotypic selection. The SAMP series includes nine substrains, each of which exhibits characteristic disorders. SAMP8 is known to exhibit age-dependent learning and memory deficits. In our previous study, we reported that brains from 12-month-old SAMP8 have greater protein oxidation, as well as lipid peroxidation, compared with brains from 4-month-old SAMP8 mice. In order to investigate the relation between age-associated oxidative stress on specific protein oxidation and age-related learning and memory deficits in SAMP8, we used proteomics to identify proteins that are expressed differently and/or modified oxidatively in aged SAMP...
Mitochondria are dynamic organelles critical for many cellular processes, including energy generatio...
We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (...
Identification of oxidized proteins in Alzheimer's disease (AD) brain is hypothesized to lead to new...
Senescence-accelerated mouse prone 8 (SAMP8) is considered as a useful animal model for age-related ...
Abstract. In order to discover and identify the key protein biomarkers in the aging process, we perf...
The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, p...
Aging is a complex process often accompanied by cognitive decline that represents a risk factor for ...
Brain function is highly dependent on a well-regulated, harmonic interaction of a multitude of cellu...
Aging remains one of the biggest unsolved problems in modern society. Oxidative stress derived from ...
Senescence accelerated mice P8 (SAMP8) is a phenotypic model of age, characterized by deficits in me...
The liver is a complex and unique organ responsible for a breadth of functions crucial to sustaining...
Aging is associated with a general decline of cognitive functions, and it is widely accepted that th...
AbstractMitochondria are dynamic organelles critical for many cellular processes, including energy g...
It is well established that the risk to develop neurodegenerative disorders increases with chronolog...
Aging is associated with a general decline in cognitive functions, which appears to be due to altera...
Mitochondria are dynamic organelles critical for many cellular processes, including energy generatio...
We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (...
Identification of oxidized proteins in Alzheimer's disease (AD) brain is hypothesized to lead to new...
Senescence-accelerated mouse prone 8 (SAMP8) is considered as a useful animal model for age-related ...
Abstract. In order to discover and identify the key protein biomarkers in the aging process, we perf...
The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, p...
Aging is a complex process often accompanied by cognitive decline that represents a risk factor for ...
Brain function is highly dependent on a well-regulated, harmonic interaction of a multitude of cellu...
Aging remains one of the biggest unsolved problems in modern society. Oxidative stress derived from ...
Senescence accelerated mice P8 (SAMP8) is a phenotypic model of age, characterized by deficits in me...
The liver is a complex and unique organ responsible for a breadth of functions crucial to sustaining...
Aging is associated with a general decline of cognitive functions, and it is widely accepted that th...
AbstractMitochondria are dynamic organelles critical for many cellular processes, including energy g...
It is well established that the risk to develop neurodegenerative disorders increases with chronolog...
Aging is associated with a general decline in cognitive functions, which appears to be due to altera...
Mitochondria are dynamic organelles critical for many cellular processes, including energy generatio...
We evaluated changes in levels by comparing serum proteins in senescence-accelerated mouse-prone 8 (...
Identification of oxidized proteins in Alzheimer's disease (AD) brain is hypothesized to lead to new...